Analgesic Powder Tetracaine HCl / Tetracaine Hydrochloride CAS 136-47-0 for Local Anesthetic
- Manufacturer: Dewael
- Product Assay: 99%+
- Appearance:white Crystalline powder.
- Place of Origin: China
- Certification: SGS,ISO9001,GMP
- Minimum Order Quantity: 10g
- Packaging Details: Discreet ways of packing for Customs pass guaranteed
- Delivery Time: Within 12 hours after receiving your payment
- Payment Terms: Western Union, MoneyGram,Bitcoin,Bank Transfer
- Shipping: EMS,DHL,Fedex,UPS,TNT and so on.
- Policy: Re-Shipping Policy
- Supply ability: 500-600kg/month
Analgesic Powder Tetracaine HCl / Tetracaine Hydrochloride CAS 136-47-0 for Local Anesthetic
Quick Detail:
Tetracaine hydrochloride Basic information |
Product Name: | Tetracaine hydrochloride |
Synonyms: | L AND OCAIN HYDROCHLORIDE;INTERCAIN HYDROCHLORIDE;MEETHOBALM HYDROCHLORIDE;2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE HYDROCHLORIDE;2-DIMETHYLAMINOETHYL ESTER OFP-BUTYLAMINOBENZOIC ACID HYDROCHLORIDE;4-(N-BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER HYDROCHLORIDE;4-[BUTYLAMINO]BENZOIC ACID-2-[DIMETHYLAMINO]ETHYL ESTER HYDROCHLORIDE;4-BUTYLAMINOBENZOIC ACID DIMETHYLAMINOETHYL ESTER HCl |
CAS: | 136-47-0 |
MF: | C15H25ClN2O2 |
MW: | 300.82 |
EINECS: | 205-248-5 |
Product Categories: | API intermediates;Sodium channel;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;PONTOCAINE;Local anesthetic |
Mol File: | 136-47-0.mol |
Tetracaine hydrochloride Description
Tetracaine is a weak base, therefore, significant changes in the rate of ionised lipid soluble drug uptake may occur with changes in the acid base balance.In vitro studies have shown that tetracaine has a high affinity for melanin, therefore, differences in duration of action may be expected between deeply pigmented eyes and less pigmented eyes.
The primary site of metabolism for tetracaine is the plasma. Pseudocholinesterases in the plasma hydrolyse tetracaine to 4-aminobenzoic acid. Unmetabolised drug is excreted in the urine.
Tetracaine hydrochloride is used as a local anaesthetic which acts by reversibly blocking the propagation and conduction of nerve impulses along nerve axons. Tetracaine stabilises the nerve membrane, preventing the increase in sodium permeability necessary for the production of an action potential.
Tetracaine hcl Usage:
1) Tetracaine Hcl For block anesthesia and epidural anesthesia.
2) Tetracaine Hcl used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
3) Tetracaine Hcl As painkillers of injection in the medicament.
4) Tetracaine Hcl used in suppository and ointment preparation,
5) Tetracaine Hcl has been used in spinal anesthesia.In biomedical research, tetracaine is used to alter the Function of calcium release channels (ryanodine receptors) that control the release of calcium from
Intracellular stores.
6) Tetracaine is an allosteric blocker of channel function.At low concentrations, Tetracaine causes an initial inhibition of spontaneous calcium release events, while at high Concentrations, tetracaine blocks release completely.
COA:
Test Items | Specification | Test Results |
Appearance | Fine, white, crystalline, odorless powder | confirm |
Identification | ABC in Pass | confirm |
Solubility | Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene | confirm |
USP Reference standards | USP Tetracaine Hydrochloride RS. USP Endotoxin RS. | confirm |
Melting point | 145~150 degree | 146.0~147.5 degree |
Chromatographic purity | In Pass | confirm |
Related substance | Not more than the reference solution 0.05% | confirm |
Heavy metals | ≤10ppm | confirm |
PH | 4.5-6.5 | 5.8 |
Residue on ignition | ≤0.10% | 0.05% |
Loss on Drying | ≤ 0.5% | 0.19% |
Assay | 98.0 -101.0% | 100.1% |
Conclusion | Confirms USP 32 |
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