Professional peptide High Purity CAS 16960-16-0 Cosyntropin with Safe Delivery

Basic Info:

Product Name:Tetracosactide,Cosyntropin,Tetracosactrin,acortan
Purity: 99%
CAS Registry Number: 16960-16-0
Einecs No: 241-031-1
MF: C136H210N40O31S
MW: 2933.47
Melting point: 2 ° C
Boiling point: 225° C
Refractive index: 1.551-1.553
Appearance: Colorless transparent liquid
Grade: Pharmceutical Grade
Storage: Shading, confined preservation
Usage: Cosyntropin (cortrosyn) is a synthetic derivative of adrenocorticotropic hormone (ACTH) that is used in the ACTH stimulation test to evaluate and diagnose cortisol disorders.

Description:

Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.

Application:

In patients with low cortisol levels or symptoms of adrenocortical insufficiency, cosyntropin can be used to diagnose Addison’s disease. A failure for serum cortisol levels to increase after administration of cosyntropin makes a diagnosis of primary adrenocortical insufficiency more likely. An increase in cortisol upon administration of cosyntropin rules out the condition. The test may also be used to assess the function of the adrenal glands after successful treatment for Cushing’s syndrome.

Cosyntropin is also used in the opposite situation, when there is aldosterone hypersecretion due to either a unilateral adrenal adenoma (which is treated by surgical removal) or bilateral adrenal hyperplasia (treated by oral). A procedure called adrenal venous sampling may be used pre-operatively to localize the source of aldosterone hypersecretion from either adrenal gland. A peripheral intravenous infusion of Cosyntropin before and during the procedure stimulates cortisol production and thereby verifies catheter position.

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