High Purity Rimonabant Weight Loss Powders Rimonabant Hydrochloride CAS 158681-13-1
- Üretici firma: Dewael
- Ürün Analizi: 99%+
- Görünüm:Beyaz Kristal Toz.
- Menşe Yeri: Çin
- Sertifikasyon: SGS,ISO9001,GMP
- Minimum Sipariş Miktarı: 10G
- Paketleme Detayları: 1 kg/folyo torba,25kg/drum or as your requirements
- Teslimat süresi: İçinde 12 ödemenizi aldıktan birkaç saat sonra
- Ödeme şartları: Batı Birliği, MoneyGram,Bitcoin,Banka transferi
- Nakliye: EMS,DHL,Fedex,GÜÇ KAYNAĞI,TNT ve benzeri.
- Politika: Yeniden Gönderim Politikası
- Tedarik yeteneği: 500-600kg/ay
High Purity Rimonabant Weight Loss Powders Rimonabant Hydrochloride CAS 158681-13-1
Detaylar:
Rimonabant hydrochloride
Ürün adı: Rimonabant hydrochloride
Eş anlamlılar: RIMONABANT HYDROCHLORIDE;5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride;ACOMPLIA;ACOMPLIA (RIMONABANT;RIMONABANT HCL;Rimonabant(Acomplia);RimonabantConsultedStandard;Acomplia, SR141716
CAS: 158681-13-1
MF: C22H21Cl3N4O.ClH
MW: 500.25
Chemical Properties White to Off-White Crystalline Solid
Usage The first of a new class of selective (Cannabinoid-1 (CB-1) receptor antagonists
Usage A brain cannabinoid receptor (CB1) antagonist. Antiobesity agent.
COA:
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Ürün adı
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Rimonabant
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CAS No.
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168273-06-1 |
Outer Packing
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1kg/bag | |
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Production date
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May 14th. 2018 |
Raf ömrü
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May 13th. 2020 | |
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Products Standard
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Kurumsal Standart | |||
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Items of analysis
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Şartname
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Sonuçlar
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| Assay by (HPLC) | 99%-101% | 99.43% | ||
| Characters/appearance | White to off White powder | Uyumludur | ||
| Odor and taste | Odorless | Uyumludur | ||
| Tanılama | Positive reaction | Uyumludur | ||
| Mesh size/sieve analysis | 100% geçmek 80 ağ | Uyumludur | ||
| Kurutma kaybı | 1% Max | 0.78% | ||
| su | ≤2.0% | 0.1% | ||
| Ateşlemede kalıntı | 01%Max | Uyumludur | ||
| Single impurity | 0.1% Max | Uyumludur | ||
| Malting point | 272.25 °C | Uyumludur | ||
| Bolling point | 627 .69 °C | Uyumludur | ||
| Refractive Index | N20O1.67 | Uyumludur | ||
| PH | 50-7.0 | 6.5 | ||
| pK Values | pK. 11.31(Predicted). pK„ 3. 22 (Predicted) | Uyumludur | ||
| çözünürlük | Soluble in ethanol (-20 mg / ml). DMSO (25 mg / ml) .DMF (-20mg / ml). and water (< 1 mg / ml) | Uyumludur | ||
| Ağır Metaller | NMT 10ppm | Uyumludur | ||
| Microbiological Control | 78CFU/G | 78CFU/G | ||
| Toplam plaka sayısı | 1000 cfu/g Max | Negatif | ||
| Fungi | <100/G | Negatif | ||
| Salmonella | Negatif | Negatif | ||
| Coll | negative | negative | ||
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Çözüm
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Qualified | |||
Rimonabant Description:
(1). Rimonabant hydrochloride (SR-141716A) is a potent and selective CB1 cannabinoid inverse agonist/antagonist with a Ki of 1.6 nM, minimal affinity for CB2, and and some GPR55 agonist activity. Rimonabant was developed as an anti-obesity drug because of its appetite suppressant activity, but was taken off the market because of side effects of depression and anxiety.
(2). Under development by Sanofi-Aventis, Acomplia (rimonabant) is a selective CB1 endocannabinoid receptor antagonist indicated for the treatment of obesity.
(3). It works by blocking endogenous cannabinoid binding to neuronal CB1 receptors. Activation of these receptors by endoegenous cannabinoids, such as anadamide, increases appetite. It is the most advanced endocannabinoid receptor antagonist in clinical development and offers a novel therapeutic approach to appetite control and weight reduction.
Rimonabant Applications:
(1). Rimonabant has a favorable safety profile and is generally well tolerated. Rimonabant is proving to be a very promising approach for managing two major and preventable risk factors for cardiovascular disease. This review summarizes the available evidence on the clinical efficacy and safety of rimonabant as a potential therapy for obesity and smoking cessation.
(2). Rimonabant hydrochloride also has potential as a treatment for smoking cessation because the endocannabinoid system is involved in the body’s response to tobacco dependence.
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