Fat Loss Powders Aldosterone Diuretic Powder Spironolactone Antisterone Aldactone for Women
- Manufacturer: Dewael
- Product Assay: 99%+
- Appearance:White fine crystalline powder.
- Place of Origin: China
- Certification: SGS,ISO9001,GMP
- Minimum Order Quantity: 10g
- Packaging Details: 1 kg/foil bag,25kg/drum or as your requirements
- Delivery Time: Within 12 hours after receiving your payment
- Payment Terms: Western Union, MoneyGram,Bitcoin,Bank Transfer
- Shipping: EMS,DHL,Fedex,UPS,TNT and so on.
- Policy: Re-Shipping Policy
- Supply ability: 500-600kg/month
Fat Loss Powders Aldosterone Diuretic Powder Spironolactone Antisterone Aldactone for Women
Details:
Synonym: Aldactone;Antisterone; spirolactone; 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,
17-beta- carbolactone
CAS: 52-01-7
EINECS: 200-133-6
MF: C24H32O4S
MW: 416.5735
Density: 1.24g / cm3
Melting point: 198-207 ºC (dec.)
Boiling point: 597 ° C at 760 mmHg
Flash Point: 302.2 ° C
Water-soluble: practically insoluble
Vapor Pressure: 3.24E-14mmHg at 25 ° C
Specific rotation: -37 ° (c = 1, CHCl3)
Spironolacton Water-soluble practically insoluble
Assay: 99%
Appearance: White or almost white fine crystalline powder
COA:
| ITEMS | STANDARDS | RESULTS |
| Appearance (Ph.Eur.) | A white or yellowish-white powder | White powder |
| Solubility (Ph.Eur.) | Practically insoluble in water, soluble in ethanol (96%) | Complies |
| Identification | ||
| A. IR -spectrum (Ph.Eur.) | Meet the requirement | Complies |
| A. IR -spectrum (USP) | Meet the requirement | Complies |
| B. TLC (Ph.Eur.) | Meet the requirement | Complies |
| B. UV absorption (USP) | Meet the requirement | Complies |
| C. Colour reaction (Ph.Eur.) | Meet the requirement | Complies |
| C. Precipitate reaction (USP) | Meet the requirement | Complies |
| Specific optical rotation | -41°~-46° | -42.8° |
| (Ph.Eur.) | -41°~-45° | -42.9° |
| (USP) | ||
| Sulphated ash (Ph.Eur.) | ≤0.1% | 0.00% |
| Related substances (Ph.Eur.) | ||
| Impurity A | ≤0.2% | N.D. |
| Impurity B | ≤0.3% | N.D. |
| Impurity C | ≤0.2% | N.D. |
| Impurity D | ≤0.15% | N.D. |
| Impurity E | ≤0.3% | N.D. |
| Impurity I | ≤0.5% | 0.05% |
| Any unspecified impurity | ≤0.10% | Complies |
| Total | ≤0.7% | 0.13% |
| Ordinary impurities (USP) | ≤2.0% | Complies |
| Free thiol compounds (Ph.Eur.) | ≤0.05mL | Complies |
| Free mercapto compounds (USP) | ≤0.10mL | Complies |
| Chromium (Ph.Eur.) | ≤50ppm | Complies |
| Assay | 97.5%~102.0% | 100.90% |
| HPLC (Ph.Eur.) | 97.5%~103.0% | 99.60% |
| HPLC (USP) | ||
| Residual solvent (In-house) | ≤3000ppm | 90ppm |
| Methanol | ≤720ppm | ≤LOD (0.0046ppm) |
| ≤880ppm | ≤LOD (0.23ppm) | |
| DMF | ||
| Particle size (In-house) | 95% ≤ 20 microns | Complies |
| Conclusion | Compiles with EP7/USP35 | |
Description:
It is a synthetic, steroidal antimineralocorticoid and antiandrogen that also has some weak progestogen properties, as well as some indirect estrogen and glucocorticoid effects. It is used primarily as a diuretic and antihypertensive, but may also be employed for the purpose of reducing elevated or unwanted androgen activity in the body. It acts predominantly as an antagonist of the mineralocorticoid (or aldosterone) and androgen receptors, and in relation to its antimineralocorticoid effects, belongs to a class of pharmaceutical drugs known as potassium-sparing diuretics.
Applications:
Spironolactone is competitive inhibition of aldosterone drugs, drug itself is not active, role is diuresis and endogenous competitive aldosterone antagonist and happen, belongs to the potassium diuretics.
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