CAS 129938-20-1 Sex Male Enhancement Powder Dapoxetine Hydrochloride Pharmaceutical Intermediates

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Описание:

Dapoxetine hydrochloride is an oral drug for the treatment of ED, used in the treatment of erectile dysfunction and premature ejaculation, erectile function impairment and premature ejaculation has very significant improvements.

There are over 1500 documents to prove the caused by different causes impotence premature ejaculation, knew the success rate is above 80%, and show its reliable curative effect, through the use of more than 20 million people worldwide, proved its long-term stability, the safety of 25 к 60 minutes of work function to coincide with a time needed for foreplay, knew the time adjustment in the highest drug concentration time, help both husband and wife a satisfactory sex life.

Dapoxetine as a new fast SSRI, a short half life, a selective 5 – HT reuptake inhibitor (SSRI), for the treatment of premature ejaculation and erectile dysfunction. Dapoxetine is a selective 5 – HT reuptake inhibitor (SSRI), such drugs widely used to treat depression and related affective disorders.
Дапоксетин, marketed as Priligy (among and other brands) is the first compound developed specially for the treatment of premature ejaculation in men 18-64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. Однако, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.

Приложения:

Treat male premature ejaculation and erectile dysfunction.Dapoxetine, marketed as (among and other brands) is the first compound developed specially for the treatment of premature ejaculation (PE) for men at th age of 18-64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, so as to delay ejaculation.. As a member of selective serotonin reuptake inhibitor (SSRI) family, Dapoxetine was initially created as an antidepressant. Однако, unlike other SSRIs, Dapoxetine is absorbed and eliminated rapidly in the body. Its fast response makes it suitable for the treatment of PE but not as an antidepressant.

Due to the lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, and Citalopram have been used as clinical drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increases IELT from two to nine times above base line in comparison of three to eight times when Dapoxetine is used. Однако, Эти СИОЗС должны принимать ежедневно, чтобы достичь значимой эффективности, and the long half-life increases the risk of the drug accumulation and as a consequence an increased adverse effects such as decreasing sexual libido and causing erectile dysfunction. Дапоксетин, с другой стороны, является быстродействующим SSRI. Он быстро поглощается и удаляется из организма в течение нескольких часов. Эта благоприятная фармакокинетика сводит к минимуму риск накопления препарата в организме, и, следовательно, уменьшая побочные эффекты.

Treat male premature ejaculation and erectile dysfunction.
Потому что отсутствие конкретного одобрения для PE в США и некоторых других странах, Другие СИОЗС, такие как флуоксетин, пароксетин, Сертралин, флувоксамин, и циталопрам использовался в качестве лекарств от маркировки для лечения PE.
Мета -анализ Уолдингера показывает, что использование этих традиционных антидепрессантов, увеличивающихся, от двух до девяти раз над базовой линией по сравнению с три -восьмикратными, когда используется дапоксетин. Однако., Эти СИОЗС должны принимать ежедневно, чтобы достичь значимой эффективности, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction.
Дапоксетин, с другой стороны, is a fast-acting SSRI.It is rapidly absorbed and eliminated from the body within a few hours.This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.Pharmacodynamics

Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor. The physiology of ejaculation primarily depends on serotonin and dopamine receptors including 5-HT1a and 5-HT2c. Dapoxetine hydrochloride prevents the reuptake of serotonin transporter. The drug binds with the reuptake transporters of norepinephrine and dopamine and inhibits the reuptake.

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