Medical Grade Yellow Orange Powder Isotretinoin Accutane for Severe Acne 4759-48-2

Detalhes:

Sinônimo: 13-cis-ra;13-cis-retinoicaci;13-ra;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780
CAS: 4759-48-2
MF: C20H28O2
MW: 300.44
EINECS: 225-296-0
Ensaio: 99%
Aparência: Orange Crystal Powder
Especificação: USP34
Chemical Property: The melting point of 174 ~ 175 Centigrade. UV maximum absorption: 354nm ( 39800). Acute toxicity of LD50 (20 dias) mice, rats by intraperitoneal injection of:904901 (mg/kg); 3389 > 4000 oral.

Isotretinoin COA:

Descrição:

Isotretinoína (INN),also known as 13-cis-retinoic acid, is an oral pharmaceutical drug primarily used to treat severe nodular acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.

Isotretinoin Usage:

Treating severe acne in patients who do not respond to other medicines. It may also be used for other conditions as determined by your doctor.
Isotretinoin is a retinoid. It works by reducing skin oil production, changing the characteristics of the skin oil, and preventing abnormal hardening of the skin.

How to use isotretinoin capsule?

Read the Medication Guide provided by your pharmacist before you start using isotretinoin and each time you get a refill. Read and sign a Patient Information/Informed Consent form before you start taking this medication. If you have any questions about isotretinoin, consult your doctor or pharmacist before taking the medication.

Swallow capsules whole. Do not crush or chew them. Isotretinoin is usually taken twice daily for 15-20 semanas, or as directed by your doctor. Directions for most generic forms of isotretinoin state that it should be taken with meals. Contudo, the FDA has indicated that the Absorica brand may be taken with or without food. Food helps increase absorption of this drug into your bloodstream. Ask your doctor or pharmacist for more information. Take this drug with a full glass of water, and do not lie down for 10 minutes after taking it.

The dosage is based on your medical condition, weight, and response to treatment.

Your acne may worsen during the first few days of taking this drug, and it may take up to 1-2 months before you notice the full benefit of this medication. If severe acne returns, a second course of treatment may be started after you have stopped taking the drug for 2 meses. The manufacturer does not recommend long-term use of isotretinoin. Do not take more than the recommended dose.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.

Isotretinoin Dosage:

The dose of isotretinoin patients receive is dependent on their weight and the severity of the condition. High-dose treatments are administered between 0.5 mg/kg/day to 2 mg/kg/day (usually at 0.5 para 1 mg/kg/day,given as a single dose with food). Usually a course will last 8–10 months. A second course may be required. Efficacy appears to be related to the cumulative dose of isotretinoin taken, with a total cumulative dose over each course of 120–150 mg/kg used as a guideline.

Nearly all patients achieve initial clearing of acne during a normal course of isotretinoin therapy. 90% of patients achieve excellent clearance of their acne after a cumulative dose of 150 mg/kg.

Lower-dosage treatments, such as 10–20 mg/day (approximately half the high dosage treatments above), can also be effective, with greatly diminished side effects.However, such lower dosage courses may be associated with higher relapse rates, requiring additional courses, especially if not taken for enough time.

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