Acting Local Anesthetic Agents Pramoxine Hydrochloride / Pramoxine HCL 637-58-1
- Manufacturer: Dewael
- Product Assay: 99%+
- Appearance:white Crystalline powder.
- Place of Origin: China
- Certification: SGS,ISO9001,GMP
- Minimum Order Quantity: 10g
- Packaging Details: Discreet ways of packing for Customs pass guaranteed
- Delivery Time: Within 12 hours after receiving your payment
- Payment Terms: Western Union, MoneyGram,Bitcoin,Bank Transfer
- Shipping: EMS,DHL,Fedex,UPS,TNT and so on.
- Policy: Re-Shipping Policy
- Supply ability: 500-600kg/month
Acting Local Anesthetic Agents Pramoxine Hydrochloride / Pramoxine HCL 637-58-1
Quick details:
| Product Name | Pramoxine Hydrochloride |
| Alias | 4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride;gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride;p-butoxyphenylgamma-morpholinopropyletherhydrochloride;proctofoam; |
| CAS NO | 637-58-1 |
| EINECS | 211-293-1 |
| Appearance | White odourless crystals |
| MF | C17H28ClNO3 |
| MW | 329.86 |
| Purity | 99% min |
| Origin | China |
| Export market | Global |
| Grade | Pharmaceutical grade |
| Supply capacity | Mass in stock |
| Usage | Muscle relaxant (smooth), lows growth of unwanted facial hair. Ropivacaine mesylate is an effective and safe alternative to ropivacaine hydrochloride in epidural anesthesia and postoperative analgesia. |
| Packing | Well disguised package to pass the customs |
| Payment | T/T, Western Union,Moneygram and Bitcoin. |
| Shipping | EMS,HKEMS,FEDEX,DHL,TNT,Aramex,etc |
| Leading time | Within 24 hours after payment. |
| Delivery time | 3-7 work days |
| 99% passing rate & 100% free resend policy | |
Description:
Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent .
Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man. Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness .
Applications:
Pramoxine is an anesthetic, or “numbing medicine.” It works by interfering with pain signals sent from the nerves to the brain.
Pramoxine topical (for the skin) is used to treat pain or itching caused by insect bites, minor burns or scrapes, hemorrhoids, and minor skin rash, dryness, or itching. Pramoxine topical is also used to treat chapped lips, and pain or skin irritation caused by coming into contact with poison ivy, poison oak, or poison sumac.
Pramoxine topical may also be used for purposes not listed in this medication guide. Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Usages
1. Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.
2. Muscle relaxant (smooth)and slows growth of unwanted facial hair.
COA:
| Product | pramoxine Hcl | ||
| Tests | Results | Specifications | |
| Description | white,crystalline powder | white to almost white,crystalline powder | |
| Solubility | Complies | Freely soluble in water and in alcohol ,soluble in chloroform,very slightly soluble in ether | |
| PH | 4.37 | About 4.5 | |
| IdentifIcation | Complies | A:By IR, To match with working standard | |
| Complies | B:By HPLC, To match with working standard | ||
| Complies | C: A solution responds to the test for Chloride | ||
| Melting point | 172.6ºC~173.5ºC | 170ºC~174ºC | |
| Loss on drying | 0.18% | ≤1.0% | |
| Residue on ignition | 0.03% | ≤0.1% | |
| Residual Solvents | Not detected | Toluene Not more than0.089% | |
| Not detected | Ethanol Not more than0.5% | ||
| 0.003% | Petroleum ether Not more than0.5% | ||
| 0.009% | Acetone Not more than0.5% | ||
| 0.006% | Methanol Not more than0.3% | ||
| Assay | 99.96% | 98.0%-102.0% (on the anhydrous basis) | |
| Conclusion: Conforms to USP36 | |||
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