Raw Estrogen Steroid Powders Estradiol CAS 50-28-2 for Estrogenic Hormone
- Manufacturer: Dewael
- Product Assay: 99%+
- Appearance:White or Almost White Crystalline Powder
- Place of Origin: China
- Certification: SGS,ISO9001,GMP
- Minimum Order Quantity: 10g
- Packaging Details: Discreet ways of packing for Customs pass guaranteed
- Delivery Time: Within 12 hours after receiving your payment
- Payment Terms: Western Union, MoneyGram,Bitcoin,Bank Transfer
- Shipping: EMS,DHL,Fedex,UPS,TNT and so on.
- Policy: Re-Shipping Policy
- Supply ability: 500-600kg/month
Raw Estrogen Steroid Powders Estradiol CAS 50-28-2 for Estrogenic Hormone
1 . Introduction
Product name: Estradiol
Other Names: 17a-Estradiol; Estra-1,3,5(10)-triene-3,17a-diol
CAS: 50-28-2
Molecular Formula: C18H24O2
Molecular Weight: 272.38
Purity: 99%
EINECS No.: 200-354-8
Grade Standard: Medicine Grade
Appearence: White or white crystalline powder
Munufacturer: Kafen
2 . Description
Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues[1] but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.
Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues. Estradiol is biosynthesized fromprogesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations. Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.
3.Applications:
Female reproduction:In the female, estradiol acts as a hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary. During the menstrual cycle, estradiol produced by the growing follicle triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation. During pregnancy, estradiol increases due to placental production. In baboons, blocking of estrogen production leads to pregnancy loss, suggesting estradiol has a role in the maintenance of pregnancy. Research is investigating the role of estrogens in the process of initiation of labor. Actions of estradiol are required before the exposure of progesterone in the luteal phase.
COA
Product name | Estradiol | |
Appearance | White crystalline powder | |
Characteristics | White or creamy white, crystalline powder | conform |
Melting point | 173 ~ 179°C | 178~ 179°C |
Specific rotation | +76°~+83° | +78.5° |
Water | ≤3.5% | pass |
Assay | 97 .0~ 103.0% | 99.07% |
Loss on drying | ≤0.5% | 0.21% |
Related substances | total impurities ≤1.0% | Pass |
any individual impurity ≤0.5% | Pass | |
Residual solvents | ethanol ≤0.5% | Pass |
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