High Purity Rimonabant Weight Loss Powders Rimonabant Hydrochloride CAS 158681-13-1
- Producent: DEWAEL
- Oznaczenie produktu: 99%+
- Wygląd:Biały krystaliczny proszek.
- Miejsce pochodzenia: Chiny
- Orzecznictwo: SGS,ISO9001, GMP
- Minimalne zamówienie: 10sol
- Szczegóły pakowania: 1 kg / folii torby,25kg / bęben lub wymagań
- Czas dostawy: W ciągu 12 godzin po otrzymaniu płatności
- Zasady płatności: western Union, MoneyGram,Bitcoin,Przelew bankowy
- Wysyłka : EMS,DHL,Fedex,UPS,TNT i tak dalej.
- Polityka: Ponowna wysyłka Polityki
- możliwość dostaw: 500-600kg / miesiąc
High Purity Rimonabant Weight Loss Powders Rimonabant Hydrochloride CAS 158681-13-1
Detale:
Rimonabant hydrochloride
Nazwa produktu: Rimonabant hydrochloride
Synonimy: RIMONABANT HYDROCHLORIDE;5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride;ACOMPLIA;ACOMPLIA (RIMONABANT;RIMONABANT HCL;Rimonabant(Acomplia);RimonabantConsultedStandard;Acomplia, SR141716
CAS: 158681-13-1
MF: C22H21Cl3N4O.ClH
MW: 500.25
Chemical Properties White to Off-White Crystalline Solid
Usage The first of a new class of selective (Cannabinoid-1 (CB-1) receptor antagonists
Usage A brain cannabinoid receptor (CB1) antagonist. Antiobesity agent.
COA:
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Nazwa produktu
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Rimonabant
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nr CAS.
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168273-06-1 |
Outer Pakowanie
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1kg/bag | |
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Data produkcji
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May 14th. 2018 |
Okres ważności
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May 13th. 2020 | |
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Products Standard
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Standard korporacyjny | |||
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Elementy analizy
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Specyfikacja
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wyniki
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| Assay by (HPLC) | 99%-101% | 99.43% | ||
| Characters/appearance | White to off White powder | Zgodny | ||
| Odor and taste | Odorless | Zgodny | ||
| Identyfikacja | Positive reaction | Zgodny | ||
| Mesh size/sieve analysis | 100% pass 80 mesh | Zgodny | ||
| Strata przy suszeniu | 1% max | 0.78% | ||
| Water | ≤2.0% | 0.1% | ||
| Pozostałość po prażeniu | 01%max | Zgodny | ||
| Single impurity | 0.1% max | Zgodny | ||
| Malting point | 272.25 °C | Zgodny | ||
| Bolling point | 627 .69 °C | Zgodny | ||
| Refractive Index | N20O1.67 | Zgodny | ||
| PH | 50-7.0 | 6.5 | ||
| pK Values | pK. 11.31(Predicted). pK„ 3. 22 (Predicted) | Zgodny | ||
| Rozpuszczalność | Soluble in ethanol (-20 mg / ml). DMSO (25 mg / ml) .DMF (-20mg / ml). and water (< 1 mg / ml) | Zgodny | ||
| Metale ciężkie | NMT 10ppm | Zgodny | ||
| Microbiological Control | 78cfu/g | 78cfu/g | ||
| Total Plate Count | 1000 cfu/g Max | Negative | ||
| Fungi | <100/sol | Negative | ||
| Salmonella | Negative | Negative | ||
| Coll | negative | negative | ||
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Wniosek
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Wykwalifikowany | |||
Rimonabant Description:
(1). Rimonabant hydrochloride (SR-141716A) is a potent and selective CB1 cannabinoid inverse agonist/antagonist with a Ki of 1.6 nM, minimal affinity for CB2, and and some GPR55 agonist activity. Rimonabant was developed as an anti-obesity drug because of its appetite suppressant activity, but was taken off the market because of side effects of depression and anxiety.
(2). Under development by Sanofi-Aventis, Acomplia (rimonabant) is a selective CB1 endocannabinoid receptor antagonist indicated for the treatment of obesity.
(3). It works by blocking endogenous cannabinoid binding to neuronal CB1 receptors. Activation of these receptors by endoegenous cannabinoids, such as anadamide, increases appetite. It is the most advanced endocannabinoid receptor antagonist in clinical development and offers a novel therapeutic approach to appetite control and weight reduction.
Rimonabant Applications:
(1). Rimonabant has a favorable safety profile and is generally well tolerated. Rimonabant is proving to be a very promising approach for managing two major and preventable risk factors for cardiovascular disease. This review summarizes the available evidence on the clinical efficacy and safety of rimonabant as a potential therapy for obesity and smoking cessation.
(2). Rimonabant hydrochloride also has potential as a treatment for smoking cessation because the endocannabinoid system is involved in the body’s response to tobacco dependence.
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