Injectable Polypeptides Deslorelin Acetate 20mg CAS 57773-65-6 for Prostate Cancer
- Fabrikant: Dewael
- product Assay: 99%+
- Uiterlijk:White lyophilized powder
- Plaats van herkomst: China
- certificaat: SGS,ISO9001, GMP
- Minimum bestelhoeveelheid: 100ml
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- Capaciteit van de levering: 500-600Liter/maand
Injectable Polypeptides Deslorelin Acetate 20mg CAS 57773-65-6 for Prostate Cancer
Snel detail:
Synoniemen:Deslorelin Acetate;[D-TRP6, DES-GLY10]-LH-RH ETHYLAMIDE;Desorelin;Des-Gly10,[d-Trp6]-Lh-Rh Ethylamide;(Des-Gly10,d-Trp6,Pro-Nhet9)-Gonadotropin-Releasing Hormone
Sequence:GLP-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET
Cas No. :57773-65-6
MF:C64H83N17O12
MW:1282.45
Puurheid (HPLC):99.0%min
Uiterlijk: White powder
Single Impurity (HPLC) :0.5%maximaal
Amino Acid Composition:±10% of theoretical
Peptide Content (N%):≥80.0%
Water Content (Karl Fischer):≤8.0%
Acetate Content (HPIC):≤12.0%
MS (ESI):Consistent
Mass Balance :95.0~105.0%
Gebruik: Induction of ovulation in estrous mares Reproduction control in dogs.
Beschrijving:
Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones.
One commercial form of Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant. Another form is available in the USA, Sucromate Equine, which was FDA-approved for use in horses in November 2010.[3] This is manufactured by Thorne BioScience LLC and was introduced to the USA market following the withdrawal of Ovuplant. The Deslorelin products are currently approved for use in veterinary medicine and to promote ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion. Suprelorin is a slowly releasing deslorelin implant used for chemical castration of dogs and ferrets. It is marketed by Virbac. Deslorelin is also used to treat benign prostate hyperplasia in dogs.
Toepassing
(1) Deslorelin acetate is an injectable gonadotropin-releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and estrogen).
(2) One commercial form of Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant…Another form is available in the USA, Surrogate Equine.
(3) The Deslorelin products are currently approved for use in veterinary medicine and to promote ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock.
(4) Deslorelin is primarily used for the initial flare effect upon the pituitary and its associated surge of LH
secretion.
(5) It is also being trialed in humans to study its efficacy in the treatment of breast cancer in women and in
treating precocious puberty and congenital adrenal hyperplasia in male and female children.
COA:
| Test van analyse | Standaard van analyse | Resultaten van analyse |
| Beschrijving | Wit kristallijn poeder | Wit kristallijn poeder |
| Identificatie | EN,UL | Positief |
| analyse | 98.0~100,5% | 99.7% |
| Verlies bij drogen | 1.0%maximaal(5mm Hg, 100 oC) | 0.2% |
| Specifieke rotatie | +34°~+40°(C=1, Chloroform) | +36.5° |
| Chromatografische zuiverheid | Total Impurities: 2.0%maximaal | <2.0% |
| Organic volatile impurities | meets the requirements. | Comforms |
| Resterende oplosmiddelen | Ethanol: 5000PPm max | 310PPm |
| Conclusie | The specification conform with USP30 standard | |
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